Section: 
Rewiews
RewiewsIgg4-related sclerosing disease of the respiratory tract: case report and literature review
D. M. Mustafaev (1), V. I. Egorov (1)
(1) Moscow Regional Scientific and Research Clinical Institute named after M. F. Vladimirskiy, Moscow, 129110, Russia
UDK: 616.22-002.17
DOI: https://doi.org/10.18692/1810-4800-2016-3-125-131
ABSTRACT
IgG4related sclerosing disease (IgG4RSD) is a recently described immunodependent system pathology, characterized by focal or diffuse inflammatory infiltration of the affected organs and tissues by plasma cells expressing IgG4, and the subsequent development of obliterate phlebitis and the relevant organs fibrosclerosis, it is accompanied by the increased levels of IgG4 in blood serum. According to recently published materials, the disease can also occur in the respiratory system. In the article, the authors describe the first documented case of IgG4RSD with isolated lesions of the larynx. The diagnosis was established by a comprehensive examination with the exception of system failures, determination of the IgG4 level in blood serum and immunohistochemical analysis of histological preparations with coloring to IgG4secreting plasma cells. After establishing the diagnosis, the patient underwent a course of systemic hormone therapy. Now the patient has persistent clinical and radiological remission of the disease.
Publication date:
30.05.2016
Keywords:
IgG4related sclerosing disease; larynx. For citation:
Mustafaev D. M., Egorov V. I. Igg4-related sclerosing disease of the respiratory tract: case report and literature review. Rossiiskaya otorinolaringologiya. 2016;3:125-131. https://doi.org/10.18692/1810-4800-2016-3-125-131