Section: 
Science articles
Science articlesExperimental substantiation of platelet enriched plasma application for stimulation of cartilage autografts regeneration
N. F. Skibitskaya (1), F. V. Semenov (1), A. A. Evglevskii (2)
(1,2) Kuban State Medical University, Krasnodar, 350063, Russia
UDK: 616.71-018.3-003.93:611-018.52/.54:616.21-089.844
DOI: https://doi.org/10.18692/1810-4800-2016-3-91-99
ABSTRACT
The objective of this work was to study the influence of platelet enriched plasma on regeneration of cartilage tissue after its mechanical destruction using morphological methods. In the process of study, withdrawal and fragmentation of cartilage tissue sections of both ear conches of rabbits was performed with subsequent reimplantation of the crushed cartilage tissue to the same place in the left ear and crushed cartilage tissue mixed with plateletenriched plasma obtained from the blood of the same laboratory animal - to the right auricle. After that a cut was made and the peculiarities of regeneration of the cartilage on the 10th, 20th days and after 1, 2 and 3 months after surgery were studied. After that the platelet enriched plasma was injected in the defect site on the right ear conch once a week. The study revealed that in the experimental group in terms of platelet enriched plasma application, regeneration of cartilage tissue occurred more adequately in comparison with the control group, and was accompanied by the acceleration of healing processes, which was expressed in activation of fibroblastic and chondroblastic of programed differentiation.
Publication date:
30.05.2016
Keywords:
cartilage tissue regeneration; chondrogenesis; platelet enriched plasma; growth factors. For citation:
Skibitskaya N. F., Semenov F. V., Evglevskii A. A. Experimental substantiation of platelet enriched plasma application for stimulation of cartilage autografts regeneration. Rossiiskaya otorinolaringologiya. 2016;3:91-99. https://doi.org/10.18692/1810-4800-2016-3-91-99