Section: 
School of pharmacotherapy
School of pharmacotherapyA new approach to elimination of nasal obstruction in intermittent allergic and acute infectious rhinitis
A. B. Kiselev (1), A. Yu. Ovchinnikov (2), T. G. Tolstikova (3), V. A. Chaukina (1), N. A. Miroshnichenko (2), N. A. Zhukova (3)
(1) State Budgetary Educational Institution of Higher Vocational Education Novosibirsk State Medical University of the Ministry of Healthcare of the Russian Federation, Novosibirsk, Russia
(2) State Budgetary Educational Institution of Higher Vocational Education A. I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
(3) Federal State Budgetary Institution of Science N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
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DOI: https://doi.org/10.18692/1810-4800-2017-2-131-136
ABSTRACT
The authors present the results of the study of decongestant effect of a cosmetic gel as a method of transcutaneous impact on nasal obstruction in intermittent allergic and acute infectious rhinitis. Preclinical study using Wistar rats on the acute formalin rhinosinusitis confirmed morphologically the presence of decongestant and anti-inflammatory effect on the mucous membrane of the nasal cavity at external gel application on the face skin. Clinical study by the method of active anterior rhinomanometry confirmed the improvement of nasal breathing in 20 minutes after the gel application on the skin of the nasal dorsum in acute infectious and allergic intermittent rhinitis. For the first time the authors proved the possibility of effecting the nasal obstruction by applying the active ingredient on the face skin.
Publication date:
06.05.2017
Keywords:
nasal obstruction, acute infectious rhinitis, allergic rhinitis, cosmetic gel. For citation:
Kiselev A. B., Ovchinnikov A. Yu., Tolstikova T. G., Chaukina V. A., Miroshnichenko N. A., Zhukova N. A. A new approach to elimination of nasal obstruction in intermittent allergic and acute infectious rhinitis. Rossiiskaya otorinolaringologiya. 2017;2:131–136. https://doi.org/10.18692/1810-4800-2017-2-131-136