Section: 
Science articles
Science articlesSystemic antibacterial therapy in otogenous and rhinogenous intracranial complications in children
A. I. Izvin (1), I. M. Veshkurtseva (1), N. E. Kuznetsova (1)
(1) Federal State Budgetary Educational Institution of Higher Vocational Education Tyumen State Medical University of the Ministry of Healthcare of Russia, Tyumen, Russia
UDK: 616.831-002.3-02:616.28+616.216.1-053.2:615.33
DOI: https://doi.org/10.18692/1810-4800-2017-2-36-40
ABSTRACT
Currently, the increase of frequency of otorhinogenous intracranial complications in children has been widely observed. It is related to the increase of microflora virulence, activation of conditionally pathogenic microorganisms as well as to the increase in their resistance to the starting antibiotic therapy. The authors studied microbial “landscape” in otorhinogenous complications in children, sensitivity to antibiotics of isolated microorganisms, the nature of the provided antimicrobial therapy in this pathology based on the data of the Children’s ENT-Department of Tyumen Oblast Clinical Hospital N 2. The leading agents in otorhinogenous intracranial complications were coagulazonegative staphylococci highly sensitive to vancomycin only. Enterococci with high sensitivity to vancomycin and Staphylococcus aureus occupied the second position. Pneumococci with sensitivity to B-lactam antibiotics ranked third. Acinetobacter lwoffii with the resistance to reserve cephalosporins, amikacin and ciprofloxacin and Candida fungi were inoculated in single cases. Empirical therapy started with protected aminopenicillins or combinations of the 3rd generation cefalosoporines with metronidazole. Antibiotic therapy correction, i.e. shift for the reserve preparations (carbapenems, 4th generation cephalosporins, inhibitor-protected cephalosporin, vancomycin) was required in more than half of the cases.
Publication date:
06.05.2017
Keywords:
оtorhinogenous intracranial complications, microbial landscape, antibiotic sensitivity, antibiotic therapy, pediatrics. For citation:
Izvin A. I., Veshkurtseva I. M., Kuznetsova N. E. Systemic antibacterial therapy in otogenous and rhinogenous intracranial complications in children. Rossiiskaya otorinolaringologiya. 2017;2:36–40. https://doi.org/10.18692/1810-4800-2017-2-36-40