Section: 
Science articles
Science articlesInverted papilloma os sinonasal localization: ethiology, patogenesis, classification and clinical issues
K. I. Sapova (1), A. N. Naumenko (1), O. I. Konoplev (1), N. N. Naumenko (2), E. V. Mukhina (3)
(1) Federal State Budgetary Institution “Saint Petersburg Research Institute of Ear, Throat, Nose and Speech”, Ministry of Health of the Russian Federation, Saint Petersburg, Russia
(2) Federal State Budgetary Institution Higher Vocational Education “North-Western State Medical University named after I. I. Mechnikov” of Ministry of Health of the Russian Federation, Saint Petersburg, Russia
(3) Saint Petersburg State University, Saint Petersburg, Russia
UDK: 616.213.6-006.52-089.87-072.1
DOI: https://doi.org/10.18692/1810-4800-2017-4-82-87
ABSTRACT
Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP.
Publication date:
25.06.2017
Keywords:
inverted papilloma, ethiology, pathogenesis, classification, clinical issues. For citation:
Sapova K. I., Naumenko A. N., Konoplev O. I., Naumenko N. N., Mukhina E. V. Inverted papilloma os sinonasal localization: ethiology, patogenesis, classification and clinical issues. Rossiiskaya otorinolaringologiya. 2017;4:82–87. https://doi.org/10.18692/1810-4800-2017-4-82-87