Section: 
Original articles
Original articlesClinical and morphological features of the middle ear cholesteatoma in children
E. A. Chernogaeva (1), O. L. Krasnogorskaya (1), P. V. Pavlov (1), R. A. Nasyrov (1)
(1) Saint Petersburg State Medical University Ministry of Healthcare of the Russia, Saint Petersburg, 194100, Russia
UDK: 616.284-002.2:616.284-002.258-053.2
DOI: https://doi.org/10.18692/1810-4800-2019-2-36-41
ABSTRACT
The authors conducted a histological study of surgical material of the patients of four age groups after the middle ear sanitizing surgery. The surgical materials were stained with the standard colorants hematoxylin and eosin using specific immunohistochemical methods. All the children were operated on at ENT clinic of SPbGPMU, for chronic suppurative otitis media with cholesteatoma in a 3-year period (from 2015 to 2018). The in-depth histological study, thorough analysis of cholesteatoma prematrix cellular composition, the level of expression of the vessel growth factors in comparison with the clinical pattern revealed the characteristic morphological features of the middle ear cholesteatoma, affecting the aggression of the chronic destructive otitises in children. The authors revealed the specific features of the histological structure of cholesteatoma in each age group. The correlation method made it possible to establish the relation between the level of vascular growth factor and the patient’s age – a more positive expressed response was observed in younger children. The authors revealed histological predictors of unfavorable cholesteatoma process, as well as the specific features of cellular composition and links of angiogenesis in each examined group. The study demonstrates the relationship of the clinical course of cholesteatoma process with its histological structure.
Publication date:
28.03.2019
Keywords:
cholesteatoma; children; pathomorphology; chronic suppurative otitis media. For citation:
Chernogaeva E. A., Krasnogorskaya O. L., Pavlov P. V., Nasyrov R. A. Clinical and morphological features of the middle ear cholesteatoma in children. Rossiiskaya otorinolaringologiya. 2019;18(2):36–41. https://doi.org/ 10.18692/1810-4800-2019-2-36-41