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Science articles
Science articlesThe dynamics of cochlear acoustic response in premature babies of the first year of life according to the factor analysis data
I. V. Rakhmanova (1), I. N. D’yakonova (1), A. G. Matroskin (1), Yu. S. Ishanova (1), A. R. Zashlyakhin (2), A. N. Radtsig (1)
(1) Pirogov Russian National Research Medical University, Moscow, 117997, Russia
(2) Morozov Children’s Municipal Clinical Hospital, Moscow, 119094, Russia
UDK: 616.282.1-053.32/.36-072.7
DOI: https://doi.org/10.18692/1810-4800-2019-5-61-66
ABSTRACT
Currently, the question of the development of the cochlea in premature children remains open. This article is devoted to the evaluation of dynamic acoustic cochlear response depending on gestation period and the age of the baby’s examination; besides, it reveals the main factor determining the functional maturation of the inner ear. The authors have examined a total of 852 children of different gestation age. The children were distributed into 4 groups according to gestation period. The first group included the children born before 28 weeks, the second – at 29 to 32 weeks, the third – at 33 to 36 weeks, and the fourth one consisted of the full-term babies (37 to 40 weeks). The children had been examined over the first year of life at the age of 3, 6 and 12 months using otoacoustic emission at the distortion product frequency. The work was carried out in 2 stages. At the first stage, the analysis of the averaged response amplitude (acoustic response power) of the cochlea for frequencies 1, 2, 4, 6 kHz, was performed both among and inside the groups. The second stage of the work consisted of the analysis of the effect of the factors (herein, the factors were the gestational period and the age of a child at the moment of the study) on the cochlea averaged response amplitude (power). In this study we used the method of principal components with varimax normalized rotation of axes in the factor space. Results: The conducted analysis of the values of the cochlear acoustic response power of 3 months old children revealed the reliable differences only in the children of groups II and III. The analysis of data both at 6 and 12 months of life has provided reliable differences in the values of the cochlear response power between groups I and III, II and III, III and IV. The intra-group comparison of the data of cochlea acoustic response power in the 1st group (before 28 weeks) did not reveal any reliable differences in various periods of examination. In group II (29–32 weeks), the reliable differences were found between the values obtained at 3 and 6 months (p = 0.007), in group III (33–36 weeks), the reliable differences were found at 3 and 12 months (p = 0.01) and in group IV (over 36 weeks), at 6 and 12 months (p = 0.036). The multiple factor analysis conducted in conclusion has shown that the main factor determining the amplitude of the cochlea acoustic response during distortion product otoacoustic emission (DPAE) is the age of gestation.
Publication date:
25.10.2019
Keywords:
premature children, acoustic function, DPAE, statistical methods. For citation:
Rakhmanova I. V., D’yakonova I. N., Matroskin A. G., Ishanova Yu. S., Zashlyakhin A. R., Radtsig A. N. The dynamics of cochlear acoustic response in premature babies of the first year of life according to the factor analysis data. Rossiiskaya otorinolaringologiya. 2019;18(5):61–66. https://doi.org/10.18692/1810-4800-2019-5-61-66