Section: 
Science articles
Science articlesCombination treatments of patients with chronic rhinosinusitis with nasal polyps
I. A. Dyukova (1), A. P. Yastremskii (2), A. V. Volodeev (1), (2)
(1) Medical and Sanitary Unit „Neftyanik“, Tyumen, 625062, Russian Federation, (2) Tyumen State Medical University, Tyumen, 625023, Russian Federation
UDK: УДК 616.211-002.2-006.5- 08-059:615.37
DOI: https://doi.org/10.18692/1810-4800-2024-2-25-30
ABSTRACT
Targeted therapy has changed the approach to the management of patients with chronic rhinosinusitis with nasal polyps (CRwNP) type 2. However, the treatment of such patients remains one of the urgent problems in otorhinolaryngology, and the search for the optimal combination of treatment methods continues. Objective. To evaluate the effectiveness of combined treatment of patients with CRwNP. Material and methods. 50 patients with CRwNP were treated with dupilumab and mometasone furoate. Patients of the main group underwent endoscopic nasal polypectomy before using these drugs. The results of computed tomography of the paranasal sinuses (Lund-Mackay score and SNOT22 (Sino-Nasal Outcome Test)) were analyzed. Results. A significant decrease in the average SNOT-22 values was revealed in patients of the main group even before the start of dupilumab injections, in subjects from the comparison group, after 8 weeks. The average values on the Lund-Mackay score in patients of the main group were 21.3±2.5 and 7.0±1.1, in the comparison group, 20±2.2 and 7.5±1.3 before and after 6 months of treatment, respectively. Conclusions. Nasal polypectomy before the start of targeted therapy in patients with CRwNP type 2 and severe nasal obstruction helps improve the quality of life according to the SNOT-22 before starting treatment with dupilumab.
Publication date:
17.04.2024
Keywords:
chronic rhinosinusitis with nasal polyps, nasal polypectomy, dupilumab. For citation:
Dyukova I. A., Yastremskii A. P., Volodeev A. V. Combination treatments of patients with chronic rhinosinusitis with nasal polyps. Russian Otorhinolaryngology. 2024;23(2):25-30. https://doi.org/10.18692/1810-4800-2024-2-25-30