Section: 
Reviews
ReviewsModern review of predictors of development and severity of juvenile-onset recurrent respiratory papillomatosis
O. M. Ignatova (1), O. V. Karneeva (2), A. S. Yunusov (3), D. P. Polyakov (4), P. I. Belavina (5)
(1), (2), (3), (4), (5) National Medical Research Center of Otolaryngology, Federal Medical and Biological Agency, Moscow, 123182, Russian Federation
UDK: УДК 616.22-006.52-031.81-036.65
DOI: https://doi.org/10.18692/1810-4800-2024-6-116-124
ABSTRACT
Abstract. Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is a benign neoplasm characterized by the uncontrolled growth of papillomas in a respiratory tract. The disease is based on a damage of the epithelium of the laryngeal mucosa by the human papillomavirus. JoRRP can have a variable course accompanied by a variety of symptoms ranging from impaired phonatory function to the development of respiratory failure and to asphyxia. Unfortunately, surgical removal of laryngeal papillomas does not solve the problem of pathology recurrence and does not affect the etiology of the disease. According to the literature, more than 70% of pediatric patients with JORRP suffer from severe recurrent forms of the disease. There is evidence that the disease may be a result of local immunosuppression. However, there is still no sufficient data in the scientific world about the causes of such a course and prerequisites for the development of JoRRP.
Publication date:
17.12.2024
Keywords:
juvenile-onset recurrent respiratory papillomatosis; laryngeal papillomatosis; human papillomavirus; pathogenesis of laryngeal papillomatosis For citation:
Ignatova O. M., Karneeva O. V., Yunusov A. S., Polyakov D. P., Belavina P. I. Modern review of predictors of development and severity of juvenile-onset recurrent respiratory papillomatosis. Russian Otorhinolaryngology. 2024;23(6):116-124. (In Russ.) https://doi.org/10.18692/1810-4800-2024-6-116-124