Section: 
Diseases of the lymphoepithelial pharyngeal ring and neck
Diseases of the lymphoepithelial pharyngeal ring and neckClinical variants of laryngeal and tracheal lesions in granulomatosis with polyangiitis (Wegener’s). Original research
I. A. Osipova (1), V. V. Vavin (2), P. I. Novikov (3)
1 MedExpert Plus, Moscow, 121170, Russian Federation, (2) Endentika Medical Cente, Moscow, 129323, Russian Federation, (3) Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation
UDK: УДК 616.323.2-007.61+617.53
DOI: https://doi.org/10.18692/1810-4800-2024-6-68-89
ABSTRACT
Abstract. The data of own observations of 41 patients with granulomatosis with polyangiitis (GPA) with involvement in the pathological process of the larynx and trachea are presented. Clinical variants of the lesion, clinical and laboratory features in generalized (GF) and local forms (LF) of GPA are considered. It has been shown that GPA with laryngeal and tracheal lesions is characterized by a younger age of patients with a predominance of women, especially with LF disease. With LF GPA with laryngeal tracheal lesion in the ANCA, the «–» status was recorded in about half of the cases of the disease, with the ANCA «+» status, ANCA MPO were more often detected. In this observation, in 90% of cases in patients, symptoms of laryngeal and tracheal lesions occurred at the onset of the disease, manifestations occurred on average 11 months before diagnosis in patients with GF and 20 months in patients with LF. The condition of the mucous membrane of the larynx and trachea can serve as a marker of local disease activity. With LF GPA, a high severity of subglottic stenosis (SGS) was characteristic, which exceeded 50% in 14 (67%) patients. Supraglottic stenosis is another possible manifestation of GPA on the part of the larynx of the trachea, in our study it was found only in LF. Tracheal stenosis (TS) was observed in about half of patients with GPA, both with GF and with LF
Publication date:
17.12.2024
Keywords:
granulomatosis with polyangiitis, generalized form, local form, subglottic laryngitis, subglottic laryngeal stenosis, supraglottic laryngeal stenosis, tracheal stenosis
For citation:
Osipova I. A., Vavin V. V., Novikov P. I. Clinical variants of laryngeal and tracheal lesions in granulomatosis with polyangiitis (Wegener’s). Original research. Russian Otorhinolaryngology. 2024;23(6):68-89. (In Russ.) https://doi.org/10.18692/1810-4800-2024-6-68-89