Section: 
School of pharmacotherapy
School of pharmacotherapyRole of angioprotective therapy in comprehensive postoperative rehabilitation of patients with cicatricial and paralytic laryngeal stenosis
A. A. Krivopalov (1), P. A. Shamkina (2), K. Sh. Sheikhametov (3), P. I. Panchenko (4), A. I. Glushenko (5), A. A. Korneenkov (6), S. S. Vysotskaya (7)
(1), (2), (3), (4), (5), (6), (7) Saint Petersburg Research Institute of Ear, Throat, Nose and Speech, Saint Petersburg, 190013, Russian Federation, (1) Mechnikov North-Western State Medical University, Saint Petersburg, 191015, Russian Federation
UDK: УДК 616.22-007.271-009.1-089.844-085
DOI: https://doi.org/10.18692/1810-4800-2025-6-120-129
ABSTRACT
Abstract. One of the adverse events associated with surgical treatment of cicatricial and paralytic laryngeal stenosis is the development of edema in the early postoperative period. In this context, the use of highly effective medications in combination therapy aimed at reducing edema is of high priority. Such medications, which have proven effective in the treatment of other conditions, include the angioprotective drug L-lysine aescinate, which has a potent anti-inflammatory and anti-exudative effect. Objective. To improve the effectiveness of postoperative care in patients with cicatricial and paralytic laryngeal stenosis by including L-lysine aescinate into combination therapy. Patients and methods. The study involved 23 patients with a verified diagnosis of laryngeal stenosis, conducted at the Saint Petersburg Research Institute of Ear, Throat, Nose, and Speech from January to October 2025. Of the total number of patients, 13 had cicatricial stenosis, and 10 had paralytic laryngeal stenosis. Surgical interventions included laryngoplasty and laser microsurgery for laryngeal stenosis. In addition to comprehensive therapy in the perioperative period, L-lysine aescinate was administered intravenously daily for 5 days. Results and discussion. The use of L-lysine aescinate in the perioperative period helped reduce the severity of reactive phenomena in the surgical area. This is evidenced by a decrease in hyperemia and edema of the laryngeal mucosa, observed on the first day after surgery, without airway obstruction. All patients showed positive improvements in respiratory function following the prescribed therapy, and none of them experienced clinically significant airway edema in the early postoperative period. Conclusions. The positive results of this clinical trial support the feasibility of further research and the possibility of incorporating L-lysine aescinate into management protocols for patients with laryngeal stenosis.
Publication date:
23.12.2025
Keywords:
laryngeal stenosis, laryngeal surgery, laryngoplasty, tissue edema, escin, L-lysine escinate For citation:
Krivopalov A. A., Shamkina P. A., Sheikhametov K. Sh., Panchenko P. I., Glushenko A. I., Korneenkov A. A., Vysotskaya S. S. Role of angioprotective therapy in comprehensive postoperative rehabilitation of patients with cicatricial and paralytic laryngeal stenosis. Russian Otorhinolaryngology. 2025;24(6):120-129. (In Russ.) https://doi.org/10.18692/1810-4800-2025-6-120-129