Section: 
School of pharmacotherapy
School of pharmacotherapyTherapeutic effect of local treatment of chronic catarrhal rhinitis with 2% aqueous solution of silver proteinate
A. B. Kiselev (1), V. A. Chaukina (1), A. S. Avtushko (1), O. S. Karimov (1), D. V. Morozov (2)
(1) State Budgetary Educational Institution of Higher Vocational Education Novosibirsk State Medical University of the Ministry of Healthcare of the Russian Federation, Novosibirsk, Russia
(2) Municipal Budgetary Institution of Healthcare of Novosibirsk Region Municipal Clinical Hospital N 1, Novosibirsk, Russia
UDK: 616.211-002.153-08-039.73
DOI: https://doi.org/10.18692/1810-4800-2017-4-129-135
ABSTRACT
The authors performed a study of comparability of therapeutic effect in chronic catarrhal rhinitis of 2% silver proteinate aqueous solution (protargol) and a modern antiseptic recommended for external application and for applications on mucous membranes. The therapeutic effect is evaluated based on its antimicrobial activity (in vitro), the dynamics of clinical symptoms over the seven-day observation period, morphological and immunohistochemical study of biopsy specimens of the nasal cavity mucosa. It is shown that the antiseptic agents protargol and octenisept have similar antimicrobial effect on microorganisms, typical of chronic catarrhal rhinitis. When applied topically both 2% protargol and octenisept as diluted 1:6 provide restoration of the epithelial barrier and its protective function, with the reduction of stress of morphofunctional state of epithelium with the tendency to normalization.
Publication date:
25.06.2017
Keywords:
chronic catarrhal rhinitis, 2% silver proteinate. For citation:
Kiselev A. B., Chaukina V. A., Avtushko A. S., Karimov O. S., Morozov D. V. Therapeutic effect of local treatment of chronic catarrhal rhinitis with 2% aqueous solution of silver proteinate. Rossiiskaya otorinolaringologiya. 2017;4:129–135. https://doi.org/10.18692/1810-4800-2017-4-129-135