Section: 
Science articles
Science articlesThe use of botulinum toxin a for improvement of bronchial tree functions in the patients with bilateral laryngeal paralysis
R. O. Stanishevskii (1), A. B. Kiselev (2)
(1) CJSC Medical Center AVICENNA of the group of companies Mother and Child, Novosibirsk, Russia
(2) State Budgetary Educational Institution of Higher Vocational Education Novosibirsk State Medical University of the Ministry of Healthcare of the Russian Federation, Novosibirsk, Russia
UDK: 616.22-009.12:616.233-073.173:615.217.34
DOI: https://doi.org/10.18692/1810-4800-2017-6-123-127
ABSTRACT
The article provides the assessment of the use of Botulinum toxin A in the treatment of patients with bilateral laryngeal paralysis (BLP), based on the study of changes of spirometry parameters FVC, FEV1, FEV / FVC, PEF, MEF75, MEF50, MEF25 and the measurement of distance between the vocal folds before and after the treatment. A clinical examination covered 19 patients with BLP, which, depending on the treatment method, were divided into 2 groups: the Ist group included 7 BLP patients, who did phonopedic exercises and respiratory gymnastics. The second group included 12 BLP patients with Botulinum toxin A injections into the larynx muscles. In the 1st group patients treatment dynamics, no significant changes have been revealed in spirometry and endoscopic control of the width of the fissure of glottis associated with phonopedic exercises and respiratory gymnastics, in the second group patients of spirometry parameters before and after the treatment were as follows: FVC – up to 3.30 after 3.55; FEV1 – up to 1.72 after 2.80; FEV / FVC – up to 52 after 78; PEF- up to 1.97 after 3.36; MEF75 – up to 1.73 after 3.03; MEF50 – up to 1.41 after 2.76; MEF25 – up to 1.25 after 1.63, the distance between the vocal folds before the preparation injection was on the average 2 mm, in 14 days after the Botulinum toxin treatment the width of the fissure of glottis averaged 5 mm.
The results of the study revealed the improvement in spirometry parameters: FVC – 41%; FEV1 – 42%; FEV/ FVC – 34%, PEF – 35%; MEF75 – 35%; MEF50 – 47%; MEF25 – 46%, the increase in the distance between the vocal folds averaged 50% according to endoscopic control. Therefore, it has been established that the use of Botulinum toxin A improves the bronchial tree patency, spirometry parameters and respiration in patients with bilateral laryngeal paralysis.
Publication date:
27.11.2017
Keywords:
bilateral laryngeal paralysis, Botulinum toxin A, forced expiratory volume, spirography, endoscopy. For citation:
Stanishevskii R. O., Kiselev A. B. The use of botulinum toxin a for improvement of bronchial tree functions in the patients with bilateral laryngeal paralysis. Rossiiskaya otorinolaringologiya. 2017;6:123–127. https://doi.org/10.18692/1810-4800-2017-6-123-127