Section: 
Science articles
Science articlesComparative assessment of the effect of course doses of vancomycin + gentamycin and vancomycin + amikacin on immature hearing analyzer
D. S. Burmistrova (1), I. N. D’yakonova (1), Yu. S. Ishanova (1), O. V. Kamkina (1), I. V. Rakhmanova (1)
(1) Federal State Budgetary Institution Higher Vocational Education “Pirogov Russian National Research Medical University“ of the Ministry of Healthcare of Russia, Moscow, Russia
UDK: 616.28-008.1-092:612.858:615.33
DOI: https://doi.org/10.18692/1810-4800-2018-2-14-18
ABSTRACT
The objective of the work is the comparative study of acoustic function of immature animals after subsequent injection of therapeutic doses of vancomycin and gentamycin (group 1) and vancomycin and amikacin (group 2). The general toxic effect was observed in the first group of animals. More expressed ototoxic effect, according to ABR and DPOAE, was observed in the second group of animals which manifested itself in a more significant rise of ABR 1st peak thresholds. The comparison of the central conduction time did not reveal any significant differences. The injection of vancomycin and gentamycin has resulted in the reduction of DPOAE evoked response at the frequencies of 4 kHz, and the injection of vancomycin and amikacin provided such reduction at the frequency of 6 kHz.
Publication date:
02.04.2018
Keywords:
rabbits, amikacin, gentamycin, vancomycin, hearing. For citation:
Burmistrova D. S., D’yakonova I. N., Ishanova Yu. S., Kamkina O. V., Rakhmanova I. V. Comparative assessment of the effect of course doses of vancomycin + gentamycin and vancomycin + amikacin on immature hearing analyzer. Rossiiskaya otorinolaringologiya. 2018;2:14–18. https://doi.org/10.18692/1810-4800-2018-2-14-18