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Science articles
Science articlesLinear discriminant analysis of indicators of blood serum laser correlation spectroscopy and oropharyngeal washings in patients with biomineralopathology
O. S. Donskaya (1), E. S. Ryazantseva (1), V. D. Margieva (1)
(1) Pavlov First Saint Petersburg State Medical University, Saint Petersburg, 197022, Russia
UDK: 616.316+616.366]-003.7+611-018.54-073.584
DOI: https://doi.org/10.18692/1810-4800-2018-6-28-31
ABSTRACT
The study of blood serum and oropharyngeal washings was conducted in the patients with biomineralopathy, associated with the inflammatory diseases of the oropharynx (urolithiasis, cholelithiasis, sialolithiasis and dental patients without systemic biomineralopathies with the large-scale deposits of tartar) using laser correlation spectroscopy (LCS) with linear discriminant analysis of indicators. The results of the study of LCS indicators revealed the common pattern of the nature of LC-shifts for all the studied biomineralopathies, distinguishing them from the control group, and the specific features of LC-spectrum for particular biomineralopathies, which can be used for biomineralopathy diagnostics based on their specific LC-shifts. The high variability of biological efficacy of low-dose chemical exposures, the complex nature of their interaction with other concomitant non-chemical factors makes it impossible to use strictly the specific markers of chemical and other anthropogenic exposures for efficient indication of the biological effects. When exposed to low doses of chemical substances, the implementation of the generated pathological state is largely determined by the functional state of the body’s adaptive resources that prevent its generation rather than by the very nature of the toxic substance. The functional disorder preceding the occurrence of persistent pathological consequences, is generated due to the multidirectional changes (shifts) on the part of numerous body systems.
Publication date:
06.12.2018
Keywords:
laser correlation spectroscopy, biomineralopathy, oropharyngeal wash, blood serum. For citation:
Donskaya O. S., Ryazantseva E. S., Margieva V. D. Linear discriminant analysis of indicators of blood serum laser correlation spectroscopy and oropharyngeal washings in patients with biomineralopathology. Rossiiskaya otorinolaringologiya. 2018;6:28–31. https://doi.org/10.18692/1810-4800-2018-6-28-31