Section: 
Science articles
Science articlesA method of reducing the frequency of local postoperative complications after laryngectomy incancer of the larynx T3N0M0
E. V. Shugakova (1), N. A. Daikhes (2), (3), A. B. Kiselev (1), V. V. Vinogradov (2), (3), S. S. Reshul’skii (2)
(1) Novosibirsk State Medical University, Novosibirsk, 630091, Russia
(2) National Medical Research Center for Otorhinolaryngology of the Federal Medico-Biological Agency of Russia, Moscow, 123182, Russia
(3) Pirogov Russian National Research Medical University, Moscow, 117997, Russia
UDK: 616.22-006.6-089.87-06
DOI: https://doi.org/10.18692/1810-4800-2020-2-74-79
ABSTRACT
The problem of healing of postoperative wounds in oncologic patients remains relevant still the present time. After laryngectomy the percentage of primary healing of postoperative wounds does not exceed 40–60%. After surgical intervention there are favorable conditions for the activation of pathogenic microorganisms of the pharyngeal mucosa. The aim of our study was to develop preventive measures to reduce the percentage of healing of postoperative wounds by means of secondary intention after laryngectomy. The course of prevention consisted in daily treatment of the pharyngeal mucosa with successively freshly prepared ozonated saline solution with an ozone content of 0.15 g/l in an amount of 3 ml; and then with a bifidobacteria probiotic in in an amount of 2 ml. After this course of prevention, the number of pathogenic and opportunistic microorganisms decreased on the pharyngeal mucosa, bifidobacteria and lactobacilli appeared. Preoperative preparation for laryngectomy by irrigation of the pharyngeal mucosa with ozonated saline solution and probiotic helps to reduce the number of local complications of infectious origin by 16.7% of cases. There is no negative effect Bifidobacterium longum MC-42 on long – term oncological.
Publication date:
13.04.2020
Keywords:
Cancer of the larynx, pharyngeal microbiota, probiotic. For citation:
Shugakova E. V., Daikhes N. A., Kiselev A. B., Vinogradov V. V., Reshul’skii S. S. A method of reducing the frequency of local postoperative complications after laryngectomy incancer of the larynx T3N0M0. Rossiiskaya otorinolaringologiya. 2020;19(2):74–79. https://doi.org/10.18692/1810-4800-2020-2-74-79