Section: 
School of pharmacotherapy
School of pharmacotherapyPerioperative management of patients with operated nasal cavity and paranasal sinuses
E. L. Savlevich (1), T. G. Pelishenko (2), V. S. Kozlov (1), F. N. Koryagin(2), T. S. Koryagina (1)
(1) Central State Medical Academy of Department for Presidential Affairs of the Russian Federation, Moscow, 121359, Russia, (2) Clinical hospital N 1 of Department for Presidential Affairs of the Russian Federation, Moscow, 121352, Russia
UDK: 616.211-089:615.38
DOI: https://doi.org/10.18692/1810-4800-2021-4-102-109
ABSTRACT
Nowadays due to the growth of the antibiotic resistance of the bacteria, the issue of the perioperative prophylaxis in surgery of the nasal cavity and paranasal sinuses has become especially relevant. Although the use of antibiotics more than 24 hours after surgery for prophylactic purposes does not increase the effectiveness of perioperative prevention of infectious complications, systemic antibiotics are often continued in the otorhinolaryngology departments for 5-7 days after surgery. Objective: Evaluation of the possibility of using of alternative antimicrobial agents in the framework of perioperative prevention of infectious complications during operations of the nasal cavity and paranasal sinuses. 178 patients undergoing surgical treatment for deviated nasal septum, chronic hypertrophic rhinitis, chronic rhinosinusitis without polyps, were divided into 2 groups. In the first group, 2 weeks before the operation and within 7 days of the postoperative period, applications were applied to the nasal cavity with a gel with Otofag bacteriophages, 2 doses 3 times a day for 60 minutes. In the second group, systemic antibiotic therapy (ceftriaxone 1.0 intramuscularly once) was prescribed 40-60 minutes before the operation. Results: There wasn’t a significant difference in the regression of reactive phenomena of the nasal mucosa and intoxication syndrome, except for the intensity of crust formation in the nasal cavity, the severity of which was 1.9 ± 0.1 points in the first and 4.19 ± 0.54 points in the second group on the 7’th day after surgery. Conclusion: The use of the gel with Otofag bacteriophages can be recommended in the perioperative period during planned operations on the nasal septum, inferior turbinates, and paranasal sinuses, which will allow avoiding the use of standard antibacterial drugs in these patients.
Publication date:
07.08.2021
Keywords:
bacteriophages, nasal septum deviation, hypertrophic rhinitis, chronic rhinosinusitis, perioperative preparation, antibiotic resistance, crust formation in the nasal cavity. For citation:
Savlevich E. L., Pelishenko T. G., Kozlov V. S., Koryagin F. N., Koryagina T. S. Perioperative management of patients with operated nasal cavity and paranasal sinuses. Rossiiskaya otorinolaringologiya. 2021;20(4):102-109. https://doi.org/10.18692/1810-4800-2021-4-102-109