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Science articles
Science articlesNeurokinin system activity of nasal cavity mucosa in rhinosinusitis with nasal polyps
D. G. Pavlush (1), E. A. Gilifanov (1), A. I. Tyutyun’kova (1), V. N. Olikyan (1), A. V. Trofimova (1), I. S. Sevost’yanova (1), N. A. Gorbach (1), V. Zh. Mizanova (1)
(1) Pacific State Medical University, Ministry of Health of Russia, Primorsky Territory, Vladivostok, 690002, Russia
UDK: 611.1-002-006.5-003.2
DOI: https://doi.org/10.18692/1810-4800-2021-4-33-42
ABSTRACT
A study of changes in the activity of elements of the neurokinin system in the tissues of the mucous membrane of the nose in patients with rhinosinusitis with nasal polyps was carried out. The object of the study was human material, polyps of the nasal cavity, and areas of the mucous membrane of the inferior turbinates. The material was obtained from female and male patients aged 30 to 75 years, a total of 70 people (50 patients in the study group and 20 patients in the control group). To solve this problem, we used immunohistochemistry to study the localization and distribution of SP (Substance undecaPeptide) and NK1 (neurokinin1)-positive elements in polyps and mucous membranes of the nose. It was found that the formation of polyposis changes in the nasal cavity is accompanied by morpho-chemical changes in the areas of the mucosa of the inferior turbinates. Analyzing the activity of SP in the nasal mucosa in control patients and patients with polyps of different types, an increase in the number of SP-positive nerve fibers and positive cellular elements of inflammatory infiltrates in the tissues of mucous membrane with an allergic type of polyp is noted. The features of the specific signaling microenvironment in the nasal cavity, providing special conditions for the formation of various types of polyposis changes, have been revealed. The specificity of the activity and distribution of markers of the inflammatory process in the tissues of polyps of different morphological types may serve as a prerequisite for the development of methods for treating this pathology.
Publication date:
07.08.2021
Keywords:
polypous rhinosinusitis, basement membrane, cysts, neurokinin receptors, substance P. For citation:
Pavlush D. G., Gilifanov E. A., Tyutyun’kova A. I., Olikyan V. N., Trofimova A. V., Sevost’yanova I. S., Gorbach N. A., Mizanova V. Zh. Neurokinin system activity of nasal cavity mucosa in rhinosinusitis with nasal polyps. Rossiiskaya otorinolaringologiya. 2021;20(4):33-42. https://doi.org/10.18692/1810-4800-2021-4-33-42