Section: 
From practice
From practiceEffect of targeted therapy for cystic fibrosis on course of pediatric chronic rhinosinusitis: first russian experience
D. P. Polyakov (1), (2), A. A. Pogodina (3), E. I. Kondrat’eva (4), (5), A. Yu. Voronkova (4), (5), A. S. Petrov (5)
(1) National Medical Research Center for Otorhinolaryngology, Federal Medical and Biological Agency, Moscow, 123182, Russia, (2) Pirogov Russian National Research Medical University, Moscow, 117997, Russia, (3) Clinical Diagnostic Center MEDSI, Moscow, 123242, Russia, (4) Academician Bochkov Medical Genetic Research Center, Moscow, 115522, Russia, (5) Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Center for Cystic Fibrosis, Moscow, 141009, Russia
UDK: УДК 616.211-002.2-053-036.1+616.24:615.357
DOI: https://doi.org/10.18692/1810-4800-2023-3-86-92
ABSTRACT
Cystic fibrosis is the most common hereditary disease characterized by multiple organ damage to the exocrine glands, one of the manifestations of which is chronic rhinosinusitis (CRS), often polyposis-purulent. A part of patients with this disease require multiple surgical interventions on the paranasal sinuses. With the arrival of targeted therapy, which intracellularly corrects the structure and function of the mutant protein and is directed primarily at treating manifestations of the lungs and pancreas, a positive effect on the course of CRS was also noted. The review of stages of development of this direction of treatment of cystic fibrosis is provided in the article, and also one of the Russia’s first similar clinical observations is given.
Publication date:
15.06.2023
Keywords:
cystic fibrosis, chronic rhinosinusitis, nasal polyposis, targeted therapy, elexacaftor. For citation:
Polyakov D. P., Pogodina A. A., Kondrat’eva E. I., Voronkova A. Yu., Petrov A. S. Effect of targeted therapy for cystic fibrosis on course of pediatric chronic rhinosinusitis: first russian experience. Russian Otorhinolaryngology. 2023;22(3):86-92. https://doi.org/10.18692/1810-4800-2023-3-86-92