Section: 
Rhinology issues
Rhinology issuesImmune mechanisms in infection-dependent allergic rhinitis: role of cytokines and chemokines
E. G. Portenko (1), R. A. Trigubenko (2), K. B. Dobrynin (3)
(1), (2), (3) Tver State Medical University, Tver, 170100, Russian Federation
UDK: УДК 616.211-002.193-056.3-085:577.27:615.37
DOI: https://doi.org/10.18692/1810-4800-2024-6-20-23
ABSTRACT
Abstract. Infectious-dependent allergic rhinitis (ISAR) remains an urgent problem in modern medicine due to the high prevalence and complexity of pathogenesis. Cytokines and chemokines that modulate inflammatory processes and the immune response play an important role in the development of the disease. Despite the active use of corticosteroids and antihistamines, existing therapies do not eliminate the problem of imbalances in the levels of these molecules induced by infectious agents. Further study of the mechanisms of their effect on the immune system is needed, which opens up new therapeutic prospects. Objective. To analyze key aspects of the role of cytokines and chemokines in the pathogenesis of ISAR as well as the mechanisms of changing their levels under the influence of infectious agents. Current therapeutic approaches aimed at modulating cytokine and chemokine activity are discussed, including the use of corticosteroids and biologics. The prospects of immunotherapy aimed at suppressing the activity of key inflammatory molecules are considered, so are the new methods, including the use of TLR agonists and targeted drugs. Conclusion. Cytokines and chemokines play a key role in the pathogenesis of ISAR by modulating inflammatory processes and the immune response.
Publication date:
17.12.2024
Keywords:
allergic rhinitis, cytokines, chemokines, immune mechanisms, infectious agents, therapeutic targets For citation:
Portenko E. G., Trigubenko R. A., Dobrynin K. B. Immune mechanisms in infection-dependent allergic rhinitis: role of cytokines and chemokines. Russian Otorhinolaryngology. 2024;23(6):20-23. (In Russ.) https://doi.org/10.18692/1810-4800-2024-6-20-23