Section: 
Rhinology issues
Rhinology issuesRole of epithelial alarmins in remodeling of mucous membrane of nasal cavity and paranasal sinuses in different phenotypes of polypous rhinosinusitis
V. I. Egorov (1), O. M. Kurbacheva (2), E. Yu. Savushkina (3), G. R. Setdikova (4), M. E. Dyneva (5), I. P. Shilovskii (6), E. D. Timotievich (7), V. I. Kovchina (8), A. A. Nikol’skii (9), M. U. Magomedov
(1), (3), (4), (10) Vladimirsky Moscow Regional Research Clinical Institute, Moscow, 129110, Russian Federation, (2), (5), (6), (7), (8), (9), (11) State Research Center Institute of Immunology of the Federal Medical and Biological Agency of Russia, Moscow, 115522, Russian Federation
UDK: УДК 616.211-002-006.5-031.81:577.27
DOI: https://doi.org/10.18692/1810-4800-2024-6-24-32
ABSTRACT
Abstract. Polypous rhinosinusitis (PRS) is a chronic disease of the mucous membrane of the nasal cavity and paranasal sinuses, the etiology of which is multifactorial. Polyps are morphologically characterized by persistent inflammation and irreversible structural changes as a result of ongoing mucosal remodeling processes. Cytokines take part in their initiation, which trigger the inflammatory process and restructuring of the mucous membrane of the respiratory tract. TSLP, IL-25, and IL-33 are among the first cytokines produced by respiratory tract epithelial cells upon contact with an antigen. All of the above leads to chronic inflammation, against which the polypous tissue becomes fibrous and, therefore, poorly responds to conservative therapy (including targeted therapy), which requires surgical intervention. Repeated operations on the nasal cavity and paranasal sinuses can lead to deformation of the facial skeleton, which worsens the quality of life of patients, their physical and mental health, and social activity. Objective. To determine the expression of the TSLP, IL-25, IL-33 genes in polypous tissue and conduct a correlation analysis with the morphological features of polypous tissue, evaluate their role in the remodeling of the mucous membrane of the nasal cavity and paranasal sinuses in different phenotypes of polypous rhinosinusitis. Conclusion. The study of the molecular and morphological features of remodeling of the mucous membrane of the nasal cavity and paranasal sinuses in different phenotypes of PRS will help in the treatment of this category of patients and the development of new drugs for targeted therapy.
Publication date:
17.12.2024
Keywords:
mucosal remodeling, PRS phenotypes, morphological features of remodeling, fibrotic process, cytokines, targeted therapy For citation:
Egorov V. I., Kurbacheva O. M., Savushkina E. Yu., Setdikova G. R., Dyneva M. E., Shilovskii I. P., Timotievich E. D., Kovchina V. I., Nikol’skii A. A., Magomedov M. U., Khaitov M. R. Role of epithelial alarmins in remodeling of mucous membrane of nasal cavity and paranasal sinuses in different phenotypes of polypous rhinosinusitis. Russian Otorhinolaryngology. 2024;23(6):24-32. (In Russ.) https://doi.or