Section: 
School of pharmacotherapy
School of pharmacotherapyA rational approach to the selection of antibacterial therapy for the treatment of upper respiratory tract infections: the role of macrolides
A. V. Gurov (1), O. V. Karneeva (2), I. A. Kim (3), G. N. Nikiforova (4), S. V. Ryazantsev (5), V. M. Svistushkin (6)
(1), (2), (3) Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation, (1) Sverzhevsky Research Clinical Institute of Otolaryngology, Moscow, 117152, Russian Federation, (2), (3) National Medical Research Center of Otolaryngology Medical and Biological Agency, Moscow, 123182, Russian Federation, (4), (6) Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russian Federation, (5) Saint Petersburg Research Institute of Ear, Throat, Nose and Speech, Saint Petersburg, 190013, Russian Federation
UDK: УДК 616.21/.231-08-039.73:615.33
DOI: https://doi.org/10.18692/1810-4800-2025-2-98-111
ABSTRACT
Abstract. Among acute inflammatory diseases of the ENT organs, acute rhinosinusitis and acute tonsillopharyngitis hold leading positions in terms of prevalence and clinical significance. The problem of selecting an adequate treatment strategy based on a rational approach to pharmacotherapy is becoming increasingly relevant. This article presents up-to-date information on existing treatment strategies for these pathological conditions, taking into account the potential etiology, clinical presentation, and severity of the disease. Special attention is given to the selection of an optimal antibacterial agent, and an algorithm for its choice is proposed. Choosing the most appropriate etiotropic drug with the required spectrum of activity is one of the most challenging tasks, as it requires consideration of various clinical and epidemiological factors. A meticulous approach to this process not only ensures a high level of efficacy in treating inflammatory conditions in individual patients but also contributes to controlling the rise of global antibiotic resistance.
Publication date:
21.04.2025
Keywords:
rhinosinusitis, tonsillopharyngitis, treatment algorithms, antibiotic resistance For citation:
Gurov A. V., Karneeva O. V., Kim I. A., Nikiforova G. N., Ryazantsev S. V., Svistushkin V. M. A rational approach to the choice of antibacterial therapy in the treatment of upper respiratory tract infections: the place of macrolides. Russian Otorhinolaryngology. 2025;24(2):98-111. (In Russ.) https://doi.org/10.18692/1810-4800-2025-2-98-111