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Science articles
Science articlesThe criteria of efficacy of polyposis rhinosinusitis treatment with activated dendritic cells
A. M. Melnik (1), M. V. Filatov (2), V. V. Dvorianchikov (1), A. V. Voronov (1), V. S. Isachenko (1)
(1) Federal State Military Educational Institution of Higher Vocational Education “Military Medical Academy named after S. M. Kirov“ of the Russian Defence Ministry, Saint Petersburg, Russia
(2) Federal State Budgetary Institution B. P. Konstantinov Petersburg Nuclear Physics Institute, Saint Petersburg, Russia
UDK: 616.216.1-006.5:615.37
DOI: https://doi.org/10.18692/1810-4800-2017-5-47-52
ABSTRACT
Molecular biology provided a fresh look at this disease and made it possible to conduct targeted therapy using the agents affecting the key components of the immune response. Many authors have shown that the failure of the sanitizing mechanisms in the patients with polypous rhinosinusitis is mainly predetermined by the system failure of the T-cell component of immune system. The current vaccination methodology based on dendritic cells lies in the fact that dendritic cells loaded with antigens are used as vaccines to provoke an immune response to pathological neoplasms target cell antigens.
The method of laser correlation spectroscopy is unique due to the fact that it can detect the formation of macromolecular complexes in complex biological systems without fractionation or any other procedures violating the native conditions of complexation and, therefore, obtain more reliable information. The study of efficacy of the ≪dendritic vaccine≫ application in reduction of chronic pathological changes in the mucous membrane of the nasal cavity and paranasal sinuses has been conducted in 5 patients aged 30 to 56 years with a long history of the disease without persistent positive effect associated with conservative and surgical treatment. The significant reduction of IgE and the increase of IgG3 in the immune complexes of this patient, accompanied by the notable improvement of the clinical state, in our opinion, constitute grounds for conclusion that the proposed procedure, after more detailed study, may be considered as a potential method of treatment of this disease.
Publication date:
02.10.2017
Keywords:
polyposis sinusitis, dendritic cells. For citation:
Melnik A. M., Filatov M. V., Dvorianchikov V. V., Voronov A. V., Isachenko V. S. The criteria of efficacy of polyposis rhinosinusitis treatment with activated dendritic cells. Rossiiskaya otorinolaringologiya. 2017;5:47–52. https://doi.org/10.18692/1810-4800-2017-5-47-52