Section: 
Reviews
ReviewsРathohistological characteristics of chronic rhinosinusitis with nasal polyps with cystic fibrosis in children
D. P. Polyakov (1), A. A. Pogodina (2), K. A. Oganyan (3)
(1) National Medical Research Center of Otorhinolaryngology of the Federal Medico-Biological Agency of the Russian Federation, Moscow, 123182, Russian Federation, (2), (3) Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation
UDK: УДК 616.211-002.2-006.5-091.8-056.7-053.2:575.224.2
DOI: https://doi.org/10.18692/1810-4800-2024-5-107-111
ABSTRACT
Abstract. Cystic fibrosis is a systemic autosomal recessive hereditary condition that is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It is characterized by severe gastrointestinal and respiratory disorders. This condition leads to dysfunction of the exocrine glands, prompting the formation of viscous mucus that interferes with mucociliary clearance. One of its characteristic manifestations of cystic fibrosis is chronic rhinosinusitis, which serves as a source of infection in the lower respiratory tract. The article provides an analysis of data from domestic and foreign literature devoted to the study of the features of the pathomorphological picture of the mucous membrane of the nasal cavity and paranasal sinuses against the background of cystic fibrosis. It is shown that there are marked differences in the structure of the mucous membrane in patients with chronic polyposis rhinosinusitis with cystic fibrosis and without it. However, all studies of pathomorphologic structure of nasal and sinus mucosa in patients with cystic fibrosis are based on rather small samples, which is a significant limitation of these studies. To further study the pathogenesis of polypous rhinosinusitis with cystic fibrosis, it is necessary to plan and conduct pathomorphological studies involving large samples of patients.
Publication date:
17.10.2024
Keywords:
cystic fibrosis, chronic rhinosinusitis, nasal polyposis, children For citation:
Polyakov D. P., Pogodina A. A., Oganyan K. A. Рathohistological characteristics of chronic rhinosinusitis with nasal polyps with cystic fibrosis in children. Russian otorhinolaryngology. 2024;23(5):107-111. (In Russ.) https://doi.org/10.18692/1810-4800-2024-5-107-111