Section: 
Reviews
ReviewsMycotic sinusitis in oncohematological patients (registry data analysis and literature review)
A. O. Charushin (1), S. N. Khostelidi (2), O. V. Shadrivova (3), A. V. Vagin (4), S. A. Vartanyan (5), I. P. Charushina (6), S. A. Artyushkin (7)
(1), (6) Аcademician E. A. Wagner Perm State Medical University, 614990, Russian Federation, (2), (3), (4), (7) Mechnikov North-Western State Medical University, 191015, Russian Federation, (5) Clinical Hospital of Emergency Medical Care, Krasnodar, 350042, Russian Federation
UDK: УДК 616.216.1-002-002.828]-06:616.15-006 (048)
DOI: https://doi.org/10.18692/1810-4800-2025-3-110-119
ABSTRACT
Abstract. The purpose of the work. To study the clinical and laboratory features of invasive mycotic sinusitis in oncohematological patients in the Russian Federation. Patients and methods. The study included 52 adult patients between 2003 and 2023. Results. The study included 52 patients with invasive fungal sinusitis (62% invasive aspergillosis, 38% mucormycosis). Men — 48%, women — 52%, median age — 46 years (from 18 to 75 years). The main background conditions were: acute myeloblastic leukemia (44%), acute lymphoblastic leukemia (19%), non-Hodgkin's lymphoma (15%), chronic lymphocytic leukemia (10%), lymphogranulomatosis (2%), multiple myeloma (4%), chronic myeloid leukemia (2%), aplastic anemia (2%), myelodysplastic syndrome (2%). The main risk factors for fungal sinusitis in oncohematological patients are polychemotherapy (88%), agranulocytosis (81%) and lymphocytopenia (67%). Organ damage ≥ 2 was detected in 83% of patients: the most common diagnosis was a combination of fungal sinusitis and lung damage (63%). It is possible to isolate the pathogen in culture only in 56% of patients. Antimycotic therapy was used in 96% of patients, surgical treatment in 35%. The overall survival rate of patients within 12 weeks was 71%.
Publication date:
17.06.2025
Keywords:
Aspergillus spp., Rhizopus spp., aspergillosis of the paranasal sinuses, fungal sinusitis, invasive aspergillosis, mucormycosis, oncohematological patients, acute leukemia, rhinoorbital mucormycosis, rhinocerebral mucormycosis For citation:
Charushin A. O., Khostelidi S. N., Shadrivova O. V., Vagin A. V., Vartanyan S. A., Charushina I. P., Artyushkin S. A. Mycotic sinusitis in oncohematological patients (registry data analysis and literature review). Russian Otorhinolaryngology. 2025;24(3):110-119. (In Russ.) https://doi.org/10.18692/1810-4800-2025-3-110-119