Section: 
Diseases of the lymphoepithelial pharyngeal ring and neck
Diseases of the lymphoepithelial pharyngeal ring and neckOral cavity changes with proton pump inhibitors in patients with laryngopharyngeal reflux
I. A. Gorbacheva (1), Yu. A. Sycheva (2), M. V. Titova (3), O. S. Donskaya (4)
(1), (2), (4) Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation, (3) St Luke’s Clinical Hospital of Saint Petersburg, Saint Petersburg, Russian Federation
UDK: УДК 616.22/.321-002:616.329.12-003-233:615.065
DOI: https://doi.org/10.18692/1810-4800-2025-2-27-33
ABSTRACT
Abstract. In modern medicine, proton pump inhibitors (PPIs) are one of the most effective treatments for gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR). However, gastroenterologists and otolaryngologists often overlook the fact that long-term use of PPIs can contribute to the development of side effects. Although PPIs are generally considered safe, a number of studies conducted in recent years have reported some side effects, including an increased risk of infections, such as intestinal infections. These side effects are believed to be associated with PPI-induced gastrointestinal dysbiosis, which is characterized by excessive growth of bacteria living in the oral cavity. The data obtained suggest that changes in the oral microbiota after taking PPIs can significantly affect the degree of intestinal dysbiosis. The effect of PPIs on oral health in patients with LPR requires further study. Thus, studying changes in the oral microbiota after PPI treatment is crucial to better understand the side effects of PPI use in patients with LPR and optimize treatment plans.
Publication date:
21.04.2025
Keywords:
laryngopharyngeal reflux; oral microbiota; proton pump inhibitors For citation:
Gorbacheva I. A., Sycheva Yu. A., Titova M. V., Donskaya O. S. Oral cavity changes with proton pump inhibitors in patients with laryngopharyngeal reflux. Russian Otorhinolaryngology. 2025;24(2):27-33. (In Russ.) https://doi.org/10.18692/1810-4800-2025-2-27-33